Background: Sepsis is a debilitating systemic disease and described as a severe and irregular systemic\ninflammatory reaction syndrome (SIRS) against infection. We employed CLP (Cecal Ligation and Puncture) model in\nrats to investigate anti-inflammatory and antioxidant effects of phloretin, as a natural antioxidant agent, and its\nprotective effect on liver tissue damage caused by sepsis.\nMethods: Male Wistar albino rats were randomly divided into three groups: sham group, CLP induced sepsis group\nand phloretin treated CLP group. Sepsis was induced by CLP method. 50 mmol/kg Phloretin was administered\nintraperitoneally in two equal doses immediately after surgery.\nResults: It was observed that blood urea nitrogen (BUN) and tumor necrosis factor alpha (TNF-�±) levels were\ndramatically increased in the CLP induced sepsis group (43.88 �± 1.905 mg/dl, 37.63 �± 1.92, respectively) when\ncompared to the sham group. Moreover, tissue Glutathione (GSH) and liver nuclear factor �¸B (NF-�¸B p65)\ntranscription factor values were higher in CLP induced sepsis group. This elevation was considerably reduced in the\nphloretin treated CLP group. No significant differences were observed in serum creatinine and creatinine\nphosphokinase levels.\nConclusions: The present study suggested that phloretin, as a natural protective agent, act against tissue damages\nintroduced following the experimental sepsis induced model, likely caused by free oxygen radicals.
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